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KMID : 0363620070280030273
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 3 p.273 ~ p.288
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The effects of Jengjengamiyjin-tang on Pancreatitis induced by DBTC in Mouse
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Choi Heung-Min
Kim Hak-Jae
Han Yi-Soo
Lim Seong-Woo
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Abstract
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Objective : We examined the effect of Jengjengamiyjin-tang, a traditional herbal formula, on the experimental pancreatitis induced by Dibutyltin Dichloride(DBTC).
Methods : 15 mice were divided into 3 groups; the normal group and the control group which were administered water only after pancreatitis elicitation and the test group which were administered Jengjengamiyjin-tang for 7 days after pancreatitis elicitation.
Results : In the activities of amylase, lipase and alkaline phosphatase in serum, the test group showed significant decrease compared with the control group after 21 days. In the common morphology and histochemical study, various injuries by hemorrhagic erosion were observed in the control group, while they were significantly decreased in the test group. In the immunohistochemical study, the manifestation of COX-1, 2, HSP27, HSP70, MAC387, Ki-67 decreased significantly in the 14th day in the test group, however, they increased in the 21st day more than the control group(p<0.05).
Conclusion : According to the above results, it is supposed that Jengjengamiyjin-tang has anti-inflammatory effect on the experimentally induced pancreatitis and may be applicable to pancreatitis especially in the acute stage.
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KEYWORD
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Jengjengamiyjin-tang, pancreatitis, dibutyltin Dichloride (DBTC), COX, HSP, MAC387, Ki-67
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